Angiogenesis in the reparatory mucosa of the mandibular edentulous ridge is driven by endothelial tip cells.
Identifieur interne : 003459 ( Main/Exploration ); précédent : 003458; suivant : 003460Angiogenesis in the reparatory mucosa of the mandibular edentulous ridge is driven by endothelial tip cells.
Auteurs : Ruxandra St Nescu [Roumanie] ; Andreea Cristiana Didilescu ; Adelina Maria Jianu ; M C RusuSource :
- Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie [ 1220-0522 ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Mandibule, Muqueuse de la bouche, Mâchoire édentée.
- cytologie : Cellules endothéliales.
- physiologie : Néovascularisation physiologique.
- Adulte, Antigènes CD34, Femelle, Humains, Mandibule, Muqueuse de la bouche, Mâle.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Antigens, CD34.
- blood supply : Mandible, Mouth Mucosa.
- cytology : Endothelial Cells.
- pathology : Jaw, Edentulous, Mandible, Mouth Mucosa.
- physiology : Neovascularization, Physiologic.
- Adult, Female, Humans, Male.
Abstract
Sprouting angiogenesis is led by specialized cell--the endothelial tip cells (ETCs) which can be targeted by pro- or anti-angiogenic therapies. We aimed to perform a qualitative study in order to assess the guidance by tip cells of the endothelial sprouts in the repairing mucosa of the edentulous mandibular crest. Mucosa of the mandibular edentulous ridge was collected from six adult patients, prior to healing abutment placement (second surgery). Slides were prepared and immunostained with antibodies for CD34 and Ki67. The abundant vasculature of the lamina propria was observed on slides and the CD34 antibodies labeled endothelial tip cells in various stages of the endothelial sprouts. Ki67 identified positive endothelial cells, confirming the proliferative status of the microvascular bed. According to the results, the in situ sprouting angiogenesis is driven by tip cells in the oral mucosa of the edentulous ridge and these cells can be targeted by various therapies, as required by the local pathologic or therapeutic conditions.
PubMed: 22732809
Affiliations:
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Maria" sort="Jianu, Adelina Maria" uniqKey="Jianu A" first="Adelina Maria" last="Jianu">Adelina Maria Jianu</name></author><author><name sortKey="Rusu, M C" sort="Rusu, M C" uniqKey="Rusu M" first="M C" last="Rusu">M C Rusu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22732809</idno><idno type="pmid">22732809</idno><idno type="wicri:Area/PubMed/Corpus">001339</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001339</idno><idno type="wicri:Area/PubMed/Curation">001339</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001339</idno><idno type="wicri:Area/PubMed/Checkpoint">001339</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001339</idno><idno type="wicri:Area/Ncbi/Merge">003F47</idno><idno type="wicri:Area/Ncbi/Curation">003F47</idno><idno 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Bucharest</wicri:regionArea><wicri:noRegion>Bucharest</wicri:noRegion></affiliation></author><author><name sortKey="Didilescu, Andreea Cristiana" sort="Didilescu, Andreea Cristiana" uniqKey="Didilescu A" first="Andreea Cristiana" last="Didilescu">Andreea Cristiana Didilescu</name></author><author><name sortKey="Jianu, Adelina Maria" sort="Jianu, Adelina Maria" uniqKey="Jianu A" first="Adelina Maria" last="Jianu">Adelina Maria Jianu</name></author><author><name sortKey="Rusu, M C" sort="Rusu, M C" uniqKey="Rusu M" first="M C" last="Rusu">M C Rusu</name></author></analytic><series><title level="j">Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie</title><idno type="ISSN">1220-0522</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antigens, CD34 (chemistry)</term><term>Endothelial Cells (cytology)</term><term>Female</term><term>Humans</term><term>Jaw, Edentulous (pathology)</term><term>Male</term><term>Mandible (blood supply)</term><term>Mandible (pathology)</term><term>Mouth Mucosa (blood supply)</term><term>Mouth Mucosa (pathology)</term><term>Neovascularization, Physiologic (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Antigènes CD34 ()</term><term>Cellules endothéliales (cytologie)</term><term>Femelle</term><term>Humains</term><term>Mandibule ()</term><term>Mandibule (anatomopathologie)</term><term>Muqueuse de la bouche ()</term><term>Muqueuse de la bouche (anatomopathologie)</term><term>Mâchoire édentée (anatomopathologie)</term><term>Mâle</term><term>Néovascularisation physiologique (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antigens, CD34</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mandibule</term><term>Muqueuse de la bouche</term><term>Mâchoire édentée</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Mandible</term><term>Mouth Mucosa</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules endothéliales</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Endothelial Cells</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Jaw, Edentulous</term><term>Mandible</term><term>Mouth Mucosa</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Néovascularisation physiologique</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neovascularization, Physiologic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Antigènes CD34</term><term>Femelle</term><term>Humains</term><term>Mandibule</term><term>Muqueuse de la bouche</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sprouting angiogenesis is led by specialized cell--the endothelial tip cells (ETCs) which can be targeted by pro- or anti-angiogenic therapies. We aimed to perform a qualitative study in order to assess the guidance by tip cells of the endothelial sprouts in the repairing mucosa of the edentulous mandibular crest. Mucosa of the mandibular edentulous ridge was collected from six adult patients, prior to healing abutment placement (second surgery). Slides were prepared and immunostained with antibodies for CD34 and Ki67. The abundant vasculature of the lamina propria was observed on slides and the CD34 antibodies labeled endothelial tip cells in various stages of the endothelial sprouts. Ki67 identified positive endothelial cells, confirming the proliferative status of the microvascular bed. According to the results, the in situ sprouting angiogenesis is driven by tip cells in the oral mucosa of the edentulous ridge and these cells can be targeted by various therapies, as required by the local pathologic or therapeutic conditions.</div></front></TEI><affiliations><list><country><li>Roumanie</li></country></list><tree><noCountry><name sortKey="Didilescu, Andreea Cristiana" sort="Didilescu, Andreea Cristiana" uniqKey="Didilescu A" first="Andreea Cristiana" last="Didilescu">Andreea Cristiana Didilescu</name><name sortKey="Jianu, Adelina Maria" sort="Jianu, Adelina Maria" uniqKey="Jianu A" first="Adelina Maria" last="Jianu">Adelina Maria Jianu</name><name sortKey="Rusu, M C" sort="Rusu, M C" uniqKey="Rusu M" first="M C" last="Rusu">M C Rusu</name></noCountry><country name="Roumanie"><noRegion><name sortKey="St Nescu, Ruxandra" sort="St Nescu, Ruxandra" uniqKey="St Nescu R" first="Ruxandra" last="St Nescu">Ruxandra St Nescu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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